an efficient green approach for the synthesis of structurally diversified spirooxindoles using sulfonic acid functionalized nanoporous silica (sba-pr-so3h)
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abstract
one-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (sba-pr-so3h) and resulted in the formation of spirooxindole dipyrimidines. spirooxindole unit is found in many natural products and biologically active molecules and 1,4-dihydropyridines are an important class of compounds with interesting biological activities such as vasolidator, antitumor, antidiabetic, bronchodilator and anti-atherosclerotic activities. excellent yields and short reaction timesare related to the highefficiency of sba-pr-so3h that the reactions take place easily in its nano-pores. mild reaction conditions and easy work-up procedures are other advantages of this green method.
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Journal title:
iranian journal of chemistry and chemical engineering (ijcce)Publisher: iranian institute of research and development in chemical industries (irdci)-acecr
ISSN 1021-9986
volume 35
issue 1 2016
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